Helicobacter pylori infection:: Epidemiology, pathophysiology, and therapy

被引：15

作者：

Crespo, A ^{[1
]}

Suh, B ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Infect Dis Sect, Philadelphia, PA 19140 USA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 06期

关键词：

Helicobacter pylori; PCR; PPI; peptic ulcer disease (PUD) MALT;

D O I：

10.1007/BF02975151

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Helicobacter pylori is one of the most commonly encountered human pathogens. It has been shown to be closely associated with peptic ulcer disease (PUD), gastric adenocarcinoma, and the gastric mucosa-associated lymphoid tissue (MALT) that may lead to gastric lymphoma. The current diagnostic methods include histology, microbiological culture, classic serology, urease activity detection, polymerase chain reaction (PCR) and stool antigen detection. Its treatment modality options are multiple; however, a triple regimen consisting of a proton pump inhibitor (PPI), and two antibiotics for 10 to 14 days is preferred. Drug resistance is a growing problem in this organism and new therapeutic options are currently limited.

引用

页码：485 / 498

页数：14

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