A new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia

被引：21

作者：

Ali, RM

Houghton, PJ

机构：

[1] Kings Coll London, Dept Pharm, Pharmacognosy Res Labs, London SW3 6LX, England

[2] Forest Res Inst Malaysia, Kuala Lumpur, Malaysia

来源：

PLANTA MEDICA | 1999年 / 65卷 / 05期

关键词：

D O I：

10.1055/s-2006-960811

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dichloromethane extract of the stem of Jacaranda filicifolia Don. showed inhibitory activity in vitro against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic acid, beta-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.

引用

页码：455 / 457

页数：3

共 8 条

[1]

ALFATAFTA AA, 1989, NAT PROD, V52, P818

[2] FLAVONOIDS AND RELATED-COMPOUNDS AS INHIBITORS OF ARACHIDONIC-ACID PEROXIDATION [J].