Role of PAR2 in pain and inflammation

被引：41

作者：

Fiorucci, S ^{[1
]}

Distrutti, E ^{[1
]}

机构：

[1] Univ Perugia, Dept Internal Med, Monteluce Policlin, I-06122 Perugia, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 04期

关键词：

D O I：

10.1016/S0165-6147(00)01932-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cell-surface protease-activated receptor (PAR) 2 is coexpressed with pro-inflammatory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) on sensory nerves, where it mediates neurogenic inflammation. New evidence now links peripheral PAR2 activation to hyperalgesic responses via release of SP in the spinal cord. Although the therapeutic exploitation of this pathway might have relevance in the generation of new analgesic drugs, caution is required because PAR2 activation is also involved in epithelial protection.

引用

页码：153 / 155

页数：3

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