Signalomic signatures enlighten drug profiling

被引：3

作者：

Abraham, RT ^{[1
]}

机构：

[1] Wyeth, Dept Oncol Discovery, Pearl River, NY 10965 USA

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 06期

关键词：

D O I：

10.1038/nchembio0606-295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When introduced into living cells, drugs frequently evoke unanticipated responses that are due either to off-target effects or to previously unknown interactions between the intended target and other biochemical pathways. The development of a panel of high-resolution sentinel assays for signal-transduction cascades in human cells promises to enhance the power of chemical genetics and increase the efficiency of drug-discovery research.

引用

页码：295 / 296

页数：3

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