Feedback control of morphogenesis in fungi by aromatic alcohols

被引:334
作者
Chen, H
Fink, GR
机构
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
关键词
aromatic alcohols; morphogenesis; quorum sensing; fungi;
D O I
10.1101/gad.1411806
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Many fungi undergo a developmental transition from a unicellular yeast form to an invasive filamentous form in response to environmental cues. Here we describe a quorum signaling pathway that links environmental sensing to morphogenesis in Saccharomyces cerevisiae. Saccharomyces cells secrete aromatic alcohols that stimulate morphogenesis by inducing the expression of FLO11 through a Tpk2p-dependent mechanism. Mutants defective in synthesis of these alcohols show reduced filamentous growth, which is partially suppressed by the addition of these aromatic alcohols. The production of these autosignaling alcohols is regulated by nitrogen: High ammonia restricts it by repressing the expression of their biosynthetic pathway, whereas nitrogen-poor conditions activate it. Moreover, the production of these aromatic alcohols is controlled by cell density and subjected to positive feedback regulation, which requires the transcription factor Aro80p. These interactions define a quorum-sensing circuit that allows Saccharomyces to respond to both cell density and the nutritional state of the environment. These same autoregulatory molecules do not evoke the morphological switch in Candida albicans, suggesting that these molecular signals are species-specific.
引用
收藏
页码:1150 / 1161
页数:12
相关论文
共 54 条
[1]   Defects arising from whole-genome duplications in Saacharomyces cerevisiae [J].
Andalis, AA ;
Storchova, Z ;
Styles, C ;
Galitski, T ;
Pellman, D ;
Fink, GR .
GENETICS, 2004, 167 (03) :1109-1121
[2]   Integration of signaling networks that regulate Dictyostelium differentiation [J].
Aubry, L ;
Firtel, R .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :469-517
[3]   Escherichia coli genes regulated by cell-to-cell signaling [J].
Baca-DeLancey, RR ;
South, MMT ;
Ding, XD ;
Rather, PN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4610-4614
[4]   Small talk: Cell-to-cell communication in bacteria [J].
Bassler, BL .
CELL, 2002, 109 (04) :421-424
[5]   The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans [J].
Biswas, K ;
Morschhäuser, J .
MOLECULAR MICROBIOLOGY, 2005, 56 (03) :649-669
[6]   Tyrosol is a quorum-sensing molecule in Candida albicans [J].
Chen, H ;
Fujita, M ;
Feng, QH ;
Clardy, J ;
Fink, GR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) :5048-5052
[7]  
Csank C, 2000, FEMS MICROBIOL LETT, V189, P115, DOI 10.1111/j.1574-6968.2000.tb09216.x
[8]   The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae [J].
Dickinson, JR ;
Eshantha, L ;
Salgado, J ;
Hewlins, MJE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8028-8034
[9]   'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts [J].
Dickinson, JR .
MICROBIOLOGY-UK, 1996, 142 :1391-1397
[10]   Cluster analysis and display of genome-wide expression patterns [J].
Eisen, MB ;
Spellman, PT ;
Brown, PO ;
Botstein, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868