Exaggerated responses to stress in the BTBR T plus tf/J mouse: An unusual behavioral phenotype

被引：54

作者：

Benno, Robert ^{[1
]}

Smirnova, Yelena ^{[1
]}

Vera, Susy ^{[1
]}

Liggett, Amanda ^{[1
]}

Schanz, Norman ^{[1
]}

机构：

[1] William Paterson Univ New Jersey, Dept Biol, Wayne, NJ 07470 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 197卷 / 02期

关键词：

BTBR mouse; Anxiety; Blood corticosterone levels; Elevated plus maze; Autism spectrum disorder; Behavior; CORPUS-CALLOSUM; PLASMA-CORTICOSTERONE; INBRED STRAINS; TASKS RELEVANT; T+TF/J MICE; AUTISM; HORMONE; MAZE; SIZE;

D O I：

10.1016/j.bbr.2008.09.041

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：462 / 465

页数：4

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