Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

被引:52
作者
Conductier, Gregory [1 ,2 ]
Brau, Frederic [1 ,2 ]
Viola, Angele [3 ]
Langlet, Fanny [4 ]
Ramkumar, Navean [2 ,5 ]
Dehouck, Benedicte [4 ]
Lemaire, Thibault [1 ,2 ]
Chapot, Raphael [1 ,2 ]
Lucas, Laurianne [1 ,2 ]
Rovere, Carole [1 ,2 ]
Maitre, Priscilla [1 ,2 ]
Hosseiny, Salma [1 ,2 ]
Petit-Paitel, Agnes [1 ,2 ]
Adamantidis, Antoine [6 ]
Lakaye, Bernard [7 ]
Risold, Pierre-Yves [8 ]
Prevot, Vincent [4 ]
Meste, Olivier [2 ,5 ]
Nahon, Jean-Louis [1 ,2 ,9 ]
Guyon, Alice [1 ,2 ]
机构
[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 7275, F-06560 Valbonne, France
[2] Univ Nice Sophia Antipolis, F-06189 Nice, France
[3] Aix Marseille Univ, Fac Med Timone, Ctr Resonance Magnet Biolog & Med, UMR 7339,CNRS, Marseille, France
[4] Univ Lille 2, INSERM, U837, Lille, France
[5] CNRS, UMR 7271, I3S, Sophia Antipolis, France
[6] Douglass Mental Hlth Univ Intitute, Montreal, PQ, Canada
[7] Univ Liege, GIGA Neurosci, Liege, Belgium
[8] Fac Med & Pharm, SFR FED 4234, EA3922, Lab Histol, Besancon, France
[9] CNRS, UPS 846, Stn Primatol, Rousset Sur Arc, France
关键词
PROTEIN-COUPLED-RECEPTORS; RAT-BRAIN; LOCALIZATION; NEURONS; SYSTEM; IDENTIFICATION; HYPOTHALAMUS;
D O I
10.1038/nn.3401
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
引用
收藏
页码:845 / U262
页数:5
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