Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

被引：52

作者：

Conductier, Gregory ^{[1
,2
]}

Brau, Frederic ^{[1
,2
]}

Viola, Angele ^{[3
]}

Langlet, Fanny ^{[4
]}

Ramkumar, Navean ^{[2
,5
]}

Dehouck, Benedicte ^{[4
]}

Lemaire, Thibault ^{[1
,2
]}

Chapot, Raphael ^{[1
,2
]}

Lucas, Laurianne ^{[1
,2
]}

Rovere, Carole ^{[1
,2
]}

Maitre, Priscilla ^{[1
,2
]}

Hosseiny, Salma ^{[1
,2
]}

Petit-Paitel, Agnes ^{[1
,2
]}

Adamantidis, Antoine ^{[6
]}

Lakaye, Bernard ^{[7
]}

Risold, Pierre-Yves ^{[8
]}

Prevot, Vincent ^{[4
]}

Meste, Olivier ^{[2
,5
]}

Nahon, Jean-Louis ^{[1
,2
,9
]}

Guyon, Alice ^{[1
,2
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 7275, F-06560 Valbonne, France

[2] Univ Nice Sophia Antipolis, F-06189 Nice, France

[3] Aix Marseille Univ, Fac Med Timone, Ctr Resonance Magnet Biolog & Med, UMR 7339,CNRS, Marseille, France

[4] Univ Lille 2, INSERM, U837, Lille, France

[5] CNRS, UMR 7271, I3S, Sophia Antipolis, France

[6] Douglass Mental Hlth Univ Intitute, Montreal, PQ, Canada

[7] Univ Liege, GIGA Neurosci, Liege, Belgium

[8] Fac Med & Pharm, SFR FED 4234, EA3922, Lab Histol, Besancon, France

[9] CNRS, UPS 846, Stn Primatol, Rousset Sur Arc, France

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 07期

关键词：

PROTEIN-COUPLED-RECEPTORS; RAT-BRAIN; LOCALIZATION; NEURONS; SYSTEM; IDENTIFICATION; HYPOTHALAMUS;

D O I：

10.1038/nn.3401

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

引用

页码：845 / U262

页数：5

共 20 条

[11] DISTRIBUTION, ACTIVITY, AND FUNCTION OF CILIA IN FROG BRAIN [J].

NELSON, DJ ;

WRIGHT, EM .

JOURNAL OF PHYSIOLOGY-LONDON, 1974, 243 (01) :63-&

[12]

PATURLELAFANECHERE L, 1994, J CELL SCI, V107, P1529

[13] In vivo characterization of brain morphometric and metabolic endophenotypes in three inbred strains of mice using magnetic resonance techniques [J].

Penet, Marie-France ;

Laigle, Christophe ;

Le Fur, Yann ;

Confort-Gouny, Sylviane ;

Heurteaux, Catherine ;

Cozzone, Patrick J. ;

Viola, Angele .

BEHAVIOR GENETICS, 2006, 36 (05) :732-744

[14] Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion [J].

Prevot, V .

JOURNAL OF NEUROENDOCRINOLOGY, 2002, 14 (03) :247-255

[15] Connexons and cell adhesion: a romantic phase [J].

Prochnow, Nora ;

Dermietzel, Rolf .

HISTOCHEMISTRY AND CELL BIOLOGY, 2008, 130 (01) :71-77

[16] Immunocytochemical localization of glycogen phosphorylase kinase in rat brain sections and in glial and neuronal primary cultures [J].

Psarra, AMG ;

Pfeiffer, B ;

Giannakopoulou, M ;

Sotiroudis, TG ;

Stylianopoulou, F ;

Hamprecht, B .

JOURNAL OF NEUROCYTOLOGY, 1998, 27 (11) :779-790

[17] Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically [J].

Stanley, Sarah ;

Pinto, Shirly ;

Segal, Jeremy ;

Perez, Cristian A. ;

Viale, Agnes ;

DeFalco, Jeff ;

Cai, XiaoLi ;

Heisler, Lora K. ;

Friedman, Jeffrey M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (15) :7024-7029

[18] Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus [J].

Tissir, Fadel ;

Qu, Yibo ;

Montcouquiol, Mireille ;

Zhou, Libing ;

Komatsu, Kouji ;

Shi, Dongbo ;

Fujimori, Toshihiko ;

Labeau, Jason ;

Tyteca, Donatienne ;

Courtoy, Pierre ;

Poumay, Yves ;

Uemura, Tadashi ;

Goffinet, Andre M. .

NATURE NEUROSCIENCE, 2010, 13 (06) :700-U71

[19] The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review [J].

Veening J.G. ;

Barendregt H.P. .

Cerebrospinal Fluid Research, 7 (1)

[20]

Vígh B, 2004, HISTOL HISTOPATHOL, V19, P607, DOI 10.14670/HH-19.607

← 1 2 →