Carboline Alkaloids from Trigonostemon lii

被引：32

作者：

Hu, Xu-Jia ^{[1
,2
,3
]}

Di, Ying-Tong ^{[1
]}

Wang, Yue-Hu ^{[1
]}

Kong, Ling-Yi

Gao, Suo ^{[1
]}

Li, Chun-Shun ^{[1
]}

Liu, Hai-Yang ^{[1
]}

He, Hong-Ping ^{[1
]}

Ding, Jian ^{[4
]}

Xie, Hua ^{[4
]}

Hao, Xiao-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Yunnan Inst Food & Drug Control, Kunming, Peoples R China

[3] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, Shanghai 200031, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 10期

关键词：

Trigonostemon lii; Euphorbiaceae; carboline alkaloids; cytotoxic activity; MEDICINAL-PLANT; REIDIOIDES; DAPHNANE; STEREOCHEMISTRY; REDIOCIDE; ROOTS; ASSAY;

D O I：

10.1055/s-0029-1185505

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three types with six new carboline alkaloids, trigonostemonines A - F (1-6), were isolated from the roots and stems of Trigonostemon lii. Their structures were elucidated by spectroscopic analyses. It is the first time that beta-carboline alkaloids have been reported in Trigonostemon species. Trigonostemonine F (6) exhibited moderate cytotoxic activity against HL-60 with an IC50 value of 16 mu M.

引用

页码：1157 / 1161

页数：5

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