Acupuncture at Both ST25 and ST37 Improves the Pain Threshold of Chronic Visceral Hypersensitivity Rats

被引：91

作者：

Liu, Hui-Rong ^{[1
]}

Wang, Xiao-Mei ^{[2
]}

Zhou, En-Hua ^{[3
]}

Shi, Yin ^{[3
]}

Li, Na ^{[3
]}

Yuan, Ling-Song ^{[3
]}

Wu, Huan-Gan ^{[3
]}

机构：

[1] Shantou Univ Med Coll, Affiliated Hosp 1, Shantou 515041, Guangdong, Peoples R China

[2] Fudan Univ, Dept Engn Sci & Mech, Shanghai 200433, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Shanghai Inst Acupuncture Moxibust & Meridians, Shanghai 200030, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2009年 / 34卷 / 11期

基金：

中国博士后科学基金;

关键词：

Electro-acupuncture; Chronic visceral hypersensitivity; Irritable bowel syndrome; 5-Hydroxytryptamine; Rat; IRRITABLE-BOWEL-SYNDROME; ELECTROACUPUNCTURE; 5-HT4; SENSITIVITY; DISTENSION; ACTIVATION; SYSTEM;

D O I：

10.1007/s11064-009-9972-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Previous studies demonstrated the efficacy of electro-acupuncture (EA) in relieving chronic visceral hypersensitivity (CVH) in IBS rats. However, ST25 which is a key acupoint for patients with IBS has not been reported in these experiments. Eight CVH rats were treated by EA at both ST25 and ST37 for 20 min, once daily for seven consecutive days, model rats (n = 8) and normal rats (n = 8) as controls. After the first EA treatment, the abdominal withdrawal reflex scores were investigated to evaluate the pain threshold. After seven EA treatments, the concentrations of 5-hydroxytryptamine (5-HT), 5-HT3 receptor (5-HT3R) and 5-HT4 receptor (5-HT4R) in colon tissue were assayed quantitatively by enzyme-linked immunosorbent assay. The results showed that EA improved the pain threshold of CVH rats, reduced the 5-HT concentration and increased the 5-HT4R concentration, but had no effect on the 5-HT3R concentration. Further studies are needed to optimize the choice of two-matching points for EA in the treatment of CVH rats.

引用

页码：1914 / 1918

页数：5

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