Migraine with aura and white matter abnormalities:: Notch3 mutation

被引：34

作者：

Ceroni, M

Poloni, TE

Tonietti, S

Fabozzi, D

Uggetti, C

Frediani, F

Simonetti, F

Malaspina, A

Alimonti, D

Celano, M

Ferrari, M

Carrera, P

机构：

[1] Univ Pavia, Dipartimento Sci Neurol, Ist Neurol IRCCS C Mondino, I-27100 Pavia, Italy

[2] Osped S Raffaele, IRCCS, Lab Biol Mol Clin, Milan, Italy

来源：

NEUROLOGY | 2000年 / 54卷 / 09期

关键词：

migraine; white matter abnormalities; Notch3; CADASIL;

D O I：

10.1212/WNL.54.9.1869

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report on an Italian family with eight affected members who show autosomal dominant migraine with prolonged visual, sensory, motor, and aphasic aura. These symptoms are associated with white matter abnormalities on brain MRI. All living affected members carry a Notch3 mutation (Arg153Cys) previously reported in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). White matter abnormalities occur in a variable percentage of the general migraine population; CADASIL should be suspected in migraineurs with prolonged atypical aura and white matter abnormalities.

引用

收藏

页码：1869 / 1871

页数：3

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