Long-term predictors of cognitive outcome in a cohort of older people with hypertension

被引:73
作者
Cervilla, JA
Prince, M
Joels, S
Lovestone, S
Mann, A
机构
[1] Inst Psychiat, London, England
[2] Royal Free Hosp, Dept Psychiat, London NW3 2QG, England
关键词
D O I
10.1192/bjp.177.1.66
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Deteriorating cognitive function in late life substantially increases the risk for dementia, for other non-cognitive morbidity, for dependency, and early death. Aims To identify early predictors of late-life cognitive outcome. Method Cognitive function, premorbid IQ, and cardiovascular risk exposure were recorded on 1083 subjects on entry to a hypertension treatment trial in 1983-1984. We followed up this cohort 9-12 years later to assess cognitive function with the Mini-Mental State Examination (MMSE), to update exposure status. and to obtain genomic material. Multivariate analysis was used to identify independent baseline predictors of cognitive outcome 9-12 years later. Results We followed up 387 subjects (58.6% of survivors). After adjusting for baseline cognition, poorer cognitive outcome was found to be independently associated with a family history of dementia, increasing age, less decline in systolic blood-pressure, lower premorbid IQ (rather than limited education), and abstinence from alcohol. Conclusions Reduction in systolic blood pressure (among hypertensives) and moderate alcohol intake could protect against cognitive deterioration in late life.
引用
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页码:66 / 71
页数:6
相关论文
共 30 条
  • [1] ALEWIJN O, 1997, STROKE, V28, P316
  • [2] [Anonymous], PERCEPT MOT SKILLS
  • [3] TREATING HYPERTENSION IN THE OLDER PERSON - AN EVALUATION OF THE ASSOCIATION OF BLOOD-PRESSURE LEVEL AND ITS REDUCTION WITH COGNITIVE PERFORMANCE
    BIRD, AS
    BLIZARD, RA
    MANN, AH
    [J]. JOURNAL OF HYPERTENSION, 1990, 8 (02) : 147 - 152
  • [4] BRAYNE C, 1988, LANCET, V1, P1265
  • [5] Sex differences in the association between alcohol consumption and cognitive performance
    Dufouil, C
    Ducimetiere, P
    Alperovitch, A
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1997, 146 (05) : 405 - 412
  • [6] UNTREATED BLOOD-PRESSURE LEVEL IS INVERSELY RELATED TO COGNITIVE-FUNCTIONING - THE FRAMINGHAM-STUDY
    ELIAS, MF
    WOLF, PA
    DAGOSTINO, RB
    COBB, J
    WHITE, LR
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1993, 138 (06) : 353 - 364
  • [7] LONGITUDINALLY MEASURED BLOOD-PRESSURE, ANTIHYPERTENSIVE MEDICATION USE, AND COGNITIVE PERFORMANCE - THE FRAMINGHAM-STUDY
    FARMER, ME
    KITTNER, SJ
    ABBOTT, RD
    WOLZ, MM
    WOLF, PA
    WHITE, LR
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1990, 43 (05) : 475 - 480
  • [8] APOLIPOPROTEIN E4 ALLELE AND COGNITIVE DECLINE IN ELDERLY MEN
    FESKENS, EJM
    HAVEKES, LM
    KALMIJN, S
    DEKNIJFF, P
    LAUNER, LJ
    KROMHOUT, D
    [J]. BRITISH MEDICAL JOURNAL, 1994, 309 (6963) : 1202 - 1206
  • [9] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
    FOLSTEIN, MF
    FOLSTEIN, SE
    MCHUGH, PR
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) : 189 - 198
  • [10] EVALUATING THE RISK OF DEPENDENCE IN ACTIVITIES OF DAILY LIVING AMONG COMMUNITY-LIVING OLDER ADULTS WITH MILD-TO-MODERATE COGNITIVE IMPAIRMENT
    GILL, TM
    RICHARDSON, ED
    TINETTI, ME
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 (05): : M235 - M241