Protocol for a national multi-centre study of magnetic resonance imaging screening in women at genetic risk of breast cancer

被引：25

作者：

Brown, J ^{[1
]}

Coulthard, A ^{[1
]}

Dixon, AK ^{[1
]}

Dixon, JM ^{[1
]}

Easton, DF ^{[1
]}

Eeles, RA ^{[1
]}

Evans, DGR ^{[1
]}

Gilbert, FG ^{[1
]}

Hayes, C ^{[1
]}

Jenkins, JPR ^{[1
]}

Leach, MO ^{[1
]}

Moss, SM ^{[1
]}

Padhani, AP ^{[1
]}

Pointon, LJ ^{[1
]}

Ponder, BAJ ^{[1
]}

Sloane, JP ^{[1
]}

Turnbull, LW ^{[1
]}

Walker, LG ^{[1
]}

Warren, RML ^{[1
]}

Watson, W ^{[1
]}

机构：

[1] Royal Marsden NHS Trust, Inst Canc Res, Sect Magnet Resonance, Study Coordinating Off, Sutton SM2 5PT, Surrey, England

来源：

BREAST | 2000年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1054/brst.2000.0136

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The protocol of the national multicentre study of Magnetic Resonance Imaging (MRI) as a method of screening for breast cancer in women at genetic risk is described. The sensitivity and specificity of contrast-enhanced MRI will be compared with two-view X-ray mammography in a comparative trial. Approximately 500 women below the age of 50 at high genetic risk of breast cancer will be recruited per year for 3 years, with annual MRI and X-ray examination continuing for up to 5 years. A symptomatic cohort will be measured in the initial phase of the study to ensure consistent reporting between centres. The MRI examination will comprise an initial high-sensitivity screening measurement, followed by a high-specificity measurement in equivocal cases. Retrospective analysis will identify the most specific indicators of malignancy. Sensitivity and specificity, together with diagnostic performance, diagnostic impact and therapeutic impact will be assessed with reference to pathology, follow-up and changes in diagnostic certainty and therapeutic decisions. The psychological impact of screening in this high-risk group will be ascertained. (C) 2000 Harcourt Publishers Ltd.

引用

页码：78 / 82

页数：5

共 8 条

[1]

Baines CJ, 1997, CANCER-AM CANCER SOC, V80, P720

[2] CYCLIC CHANGES IN COMPOSITION AND VOLUME OF THE BREAST DURING THE MENSTRUAL-CYCLE, MEASURED BY MAGNETIC-RESONANCE-IMAGING [J].