A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres

被引：29

作者：

Narumi, Tetsuo

Niida, Ayumu

Tomita, Kenji

Oishi, Shinya

Otaka, Akira

Ohno, Hiroaki

Fujii, Nobutaka ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 45期

关键词：

D O I：

10.1039/b608596b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By a novel one-pot reaction sequence involving consecutive organocopper-mediated reduction, transmetalation and asymmetric alkylation, a highly diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres was achieved in good to excellent yields.

引用

收藏

页码：4720 / 4722

页数：3

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