Purification of a factor that enhances the antibacterial activity of beta-lactams against methicillin-resistant Staphylococcus aureus: Its identification as undecaphosphotungstate

被引：17

作者：

Tajima, Y ^{[1
]}

机构：

[1] CHEM ASSAY CTR,SAGA,JAPAN

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1997年 / 68卷 / 02期

关键词：

D O I：

10.1016/S0162-0134(97)00049-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, a factor (Factor T) was found in aged mixtures of tungstate and phosphate, which greatly enhances the antibacterial effects of beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus. Factor T was purified and identified as undecaphosphotungstate ([PW11O39](7-)). Undecasilicotungstate ([SiW11O39](8-)), a compound closely related to undecaphosphotungstate, showed a similar enhancing effect. (C) 1997 Elsevier Science Inc.

引用

页码：93 / 99

页数：7

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