Alzheimer's centennial legacy:: prospects for rational therapeutic intervention targeting the Aβ amyloid pathway

被引：117

作者：

Masters, Colin L. ^{[1
]}

Beyreuther, Konrad

机构：

[1] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[2] Mental Hlth Res Inst, Parkville, Vic, Australia

[3] Heidelberg Univ, Ctr Mol Biol, Heidelberg, Germany

来源：

BRAIN | 2006年 / 129卷

基金：

英国医学研究理事会;

关键词：

A beta amyloid pathway; Alzheimer's disease; amyloid beta precursor protein;

D O I：

10.1093/brain/awl251

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the first 80 years, very little progress was made in understanding the mechanisms that caused the brain to degenerate in a remarkably specific fashion (amyloid accumulation with neurofibrillary changes). Over the past 20 years, there has been an explosion of knowledge which continues today at an exponential rate. The molecular pathways underlying the synaptic dysfunction in Alzheimer's disease have delivered many validated therapeutic and diagnostic targets. A variety of therapeutic strategies aimed at disease modification are now in clinical development.

引用

页码：2823 / 2839

页数：17

共 194 条

[1] Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease [J].

Adlard, PA ;

Perreau, VM ;

Pop, V ;

Cotman, CW .

JOURNAL OF NEUROSCIENCE, 2005, 25 (17) :4217-4221

[2] A 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer's disease [J].

Alvarez, XA ;

Cacabelos, R ;

Laredo, M ;

Couceiro, V ;

Sampedro, C ;

Varela, M ;

Corzo, L ;

Fernandez-Novoa, L ;

Vargas, M ;

Aleixandre, M ;

Linares, C ;

Granizo, E ;

Muresanu, D ;

Moessler, H .

EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (01) :43-54

[3] Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897 [J].

Anderson, JJ ;

Holtz, G ;

Baskin, PP ;

Turner, M ;

Rowe, B ;

Wang, BW ;

Kounnas, MZ ;

Lamb, BT ;

Barten, D ;

Felsenstein, K ;

McDonald, I ;

Srinivasan, K ;

Munoz, B ;

Wagner, SL .

BIOCHEMICAL PHARMACOLOGY, 2005, 69 (04) :689-698

[4] Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies [J].

Arbel, M ;

Yacoby, I ;

Solomon, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7718-7723

[5] Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Aβ antibody [J].

Bales, KR ;

Tzavara, ET ;

Wu, S ;

Wade, MR ;

Bymaster, FP ;

Paul, SM ;

Nomikos, GG .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :825-832

[6] Effects of a behaviorally active antibody on the brain uptake and clearance of amyloid beta proteins [J].

Banks, WA ;

Pagliari, P ;

Nakaoke, R ;

Morley, JE .

PEPTIDES, 2005, 26 (02) :287-294

[7] Globular amyloid β-peptide1-42 oligomer -: a homogenous and stable neuropathological protein in Alzheimer's disease [J].

Barghorn, S ;

Nimmrich, V ;

Striebinger, A ;

Krantz, C ;

Keller, P ;

Janson, B ;

Bahr, M ;

Schmidt, M ;

Bitner, RS ;

Harlan, J ;

Barlow, E ;

Ebert, U ;

Hillen, H .

JOURNAL OF NEUROCHEMISTRY, 2005, 95 (03) :834-847

[8] Delineating common molecular mechanisms in Alzheimer's and prion diseases [J].

Barnham, Kevin J. ;

Cappai, Roberto ;

Beyreuther, Konrad ;

Masters, Colin L. ;

Hill, Andrew F. .

TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (08) :465-472

[9] Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β-amyloid [J].

Barnham, KJ ;

Haeffner, F ;

Ciccotosto, GD ;

Curtain, CC ;

Tew, D ;

Mavros, C ;

Beyreuther, K ;

Carrington, D ;

Masters, CL ;

Cherny, RA ;

Cappai, R ;

Bush, AI .

FASEB JOURNAL, 2004, 18 (10) :1427-+

[10] Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation [J].

Barnham, KJ ;

Ciccotosto, GD ;

Tickler, AK ;

Ali, FE ;

Smith, DG ;

Williamson, NA ;

Lam, YH ;

Carrington, D ;

Tew, D ;

Kocak, G ;

Volitakis, I ;

Separovic, F ;

Barrow, CJ ;

Wade, JD ;

Masters, CL ;

Cherny, RA ;

Curtain, CC ;

Bush, AI ;

Cappai, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) :42959-42965

← 1 2 3 4 5 6 7 8 9 10 →