A convergent synthesis of an LTD(4) antagonist, RG12525

被引：6

作者：

Sledeski, AW

OBrien, MK

Truesdale, LK

机构：

[1] Process Chemistry, Rhône-Poulenc Rorer Ctrl. Res., Collegeville, PA 19426, PLT

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(96)02460-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, convergent synthesis of an LTD(4) antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described. (C) 1997, Elsevier Science Ltd.

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页码：1129 / 1132

页数：4

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