PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

被引：633

作者：

Marte, BM

Downward, J

机构：

[1] Imperial Cancer Research Fund, London, WC2A 3PX

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(97)01097-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.

引用

页码：355 / 358

页数：4

共 41 条

[1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
Alessi, DR
James, SR
Downes, CP
Holmes, AB
Gaffney, PRJ
Reese, CB
Cohen, P
[J]. CURRENT BIOLOGY, 1997, 7 (04) : 261 - 269
[2] Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase
Alessi, DR
Caudwell, FB
Andjelkovic, M
Hemmings, BA
Cohen, P
[J]. FEBS LETTERS, 1996, 399 (03) : 333 - 338
[3] Mechanism of activation of protein kinase B by insulin and IGF-1
Alessi, DR
Andjelkovic, M
Caudwell, B
Cron, P
Morrice, N
Cohen, P
Hemmings, BA
[J]. EMBO JOURNAL, 1996, 15 (23) : 6541 - 6551
[4] Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
Andjelkovic, M
Jakubowicz, T
Cron, P
Ming, XF
Han, JW
Hemmings, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 5699 - 5704
[5] MOLECULAR ALTERATIONS OF THE AKT2 ONCOGENE IN OVARIAN AND BREAST CARCINOMAS
BELLACOSA, A
DEFEO, D
GODWIN, AK
BELL, DW
CHENG, JQ
ALTOMARE, DA
WAN, MH
DUBEAU, L
SCAMBIA, G
MASCIULLO, V
FERRANDINA, G
PANICI, PB
MANCUSO, S
NERI, G
TESTA, JR
[J]. INTERNATIONAL JOURNAL OF CANCER, 1995, 64 (04) : 280 - 285
[6] A RETROVIRAL ONCOGENE, AKT, ENCODING A SERINE-THREONINE KINASE CONTAINING AN SH2-LIKE REGION
BELLACOSA, A
TESTA, JR
STAAL, SP
TSICHLIS, PN
[J]. SCIENCE, 1991, 254 (5029) : 274 - 277
[7] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION
BURGERING, BMT
COFFER, PJ
[J]. NATURE, 1995, 376 (6541) : 599 - 602
[8] Amplification of AKT2 in human pancreatic cancer cells and inhibition of ATK2 expression and tumorigenicity by antisense RNA
Cheng, JQ
Ruggeri, B
Klein, WM
Sonoda, G
Altomare, DA
Watson, DK
Testa, JR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) : 3636 - 3641
[9] MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL PUTATIVE PROTEIN-SERINE KINASE RELATED TO THE CAMP-DEPENDENT AND PROTEIN-KINASE-C FAMILIES
COFFER, PJ
WOODGETT, JR
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 201 (02): : 475 - 481
[10] INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN-MEDIATED BY PROTEIN-KINASE-B
CROSS, DAE
ALESSI, DR
COHEN, P
ANDJELKOVICH, M
HEMMINGS, BA
[J]. NATURE, 1995, 378 (6559) : 785 - 789

← 1 2 3 4 5 →