New insights regarding HLA-B27 diversity in the Asian population

被引：67

作者：

García-Fernández, S

Gonzalez, S

Blanco, AM

Martinez-Borra, J

Blanco-Gelaz, M

López-Vazquez, A

López-Larrea, C

机构：

[1] Hosp Cent Asturias, Dept Immunol, E-33006 Oviedo, Spain

[2] Univ Oviedo, Funct Biol Dept, Oviedo, Spain

来源：

TISSUE ANTIGENS | 2001年 / 58卷 / 04期

关键词：

HLA-B27; alleles; B*2714; B*2715; ankylosing spondylitis; Asians; PCR-SSP;

D O I：

10.1034/j.1399-0039.2001.580407.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A polymerase chain reaction-sequence-specific primer (PCR-SSP) method which distinguishes all B27 alleles described at present (B*2701-23) has been developed. The distribution of B27 alleles was characterised in six different Asian populations. HLA-B*2705, 02, 04, 07, 22 (formerly B*2706) subtypes found in Asian populations differ in their ethnic distribution, which may be the result of different genetic and geographic origins, Furthermore, two novel B27 alleles were found in this study. B*2714 was identified in two Siberians, one of whom was a patient with ankylosing spondylitis. B*2715 was found in two patients with ankylosing spondylitis in Thais. These associations have not previously been reported in either ethnic group.

引用

页码：259 / 262

页数：4

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