Gene expression and fast construction of distributed evolutionary representation

被引:25
作者
Kargupta, H [1 ]
Park, BH [1 ]
机构
[1] Washington State Univ, Sch EECS, Pullman, WA 99164 USA
关键词
gene expression; representation construction; Walsh analysis; linkage learning;
D O I
10.1162/10636560151075112
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
The gene expression process in nature produces different proteins in different cells from different portions of the DNA. Since proteins control almost every important activity in a living organism, at an abstract level, gene expression can be viewed as a process that evaluates the merit or "fitness" of the DNA. This distributed evaluation of the DNA would not be possible without a decomposed representation of the fitness function defined over the DNAs. This paper argues that, unless the living body was provided with such a representation, we have every reason to believe that it must have an efficient mechanism to construct this distributed representation. This paper demonstrates Polynomial-time computability of such a representation by proposing a class of efficient algorithms, The main contribution of this paper is two-fold. On the algorithmic side, it offers a way to scale up evolutionary search by detecting the underlying structure of the search space. On the biological side, it proves that the distributed representation of the evolutionary fitness function in gene expression can be computed in polynomial-time. It advances our understanding about the representation construction mi gene expression from the perspective of computing. It also presents experimental results supporting the theoretical performance of the proposed algorithms.
引用
收藏
页码:43 / 69
页数:27
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