Bioactive sesquiterpenes from Santolina rosmarinifolia subsp, Canescens.: A conformational analysis of the germacrane ring

被引：45

作者：

Barrero, AF

Herrador, MM

Quilez, JF

Alvarez-Manzaneda, R

Portal, D

Gavin, JA

Gravalos, DG

Simmonds, MSJ

Blaney, WM

机构：

[1] Univ Granada, Inst Biotecnol, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain

[2] Univ Almeria, Fac Ciencias Expt, Dept Quim Organ, Almeria 04120, Spain

[3] Inst Univ Bioorgan Antonio Gonzalez, Tenerife, Spain

[4] Pharma Mar SA, Madrid 28760, Spain

[5] Royal Bot Gardens, Jodrell Lab, Richmond, Surrey, England

[6] Birkbeck Coll, Dept Biol, London, England

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 04期

关键词：

Santolina rosmarinifolia subsp canescens; compositae; sesquiterpenes; conformational study; biological activities; antifeedants;

D O I：

10.1016/S0031-9422(99)00047-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was carried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and antitumoral activity of selected compounds has been tested. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：529 / 541

页数：13

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