Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation

被引:54
作者
Zhou, Jiansong [1 ]
Li, Lingjiang [1 ,5 ]
Tang, Shaojun [2 ]
Cao, Xia [3 ]
Li, Zexuan [1 ]
Li, Weihui [1 ]
Li, Changqi [4 ]
Zhang, Xianghui [1 ]
机构
[1] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
[2] Univ Calif Irvine, Ctr Neuorbiol Learning & Memory, Irvine, CA 92697 USA
[3] Cent S Univ, Xiangya Hosp 3, Changsha 410078, Hunan, Peoples R China
[4] Cent S Univ, Dept Anat, Changsha 410078, Hunan, Peoples R China
[5] Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
Hippocampus; Glucocorticoid receptor; BDNF; Stress; Adaptation;
D O I
10.1016/j.bbr.2008.06.009
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:129 / 138
页数:10
相关论文
共 62 条
[1]
Neurotrophins and depression [J].
Altar, CA .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (02) :59-61
[2]
The role of corticotropin-releasing factor in depression and anxiety disorders [J].
Arborelius, L ;
Owens, MJ ;
Plotsky, PM ;
Nemeroff, CB .
JOURNAL OF ENDOCRINOLOGY, 1999, 160 (01) :1-12
[3]
CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].
ARRIZA, JL ;
WEINBERGER, C ;
CERELLI, G ;
GLASER, TM ;
HANDELIN, BL ;
HOUSMAN, DE ;
EVANS, RM .
SCIENCE, 1987, 237 (4812) :268-275
[4]
Psychological stress and neuroendocrine function in humans: The last two decades of research [J].
Biondi, M ;
Picardi, A .
PSYCHOTHERAPY AND PSYCHOSOMATICS, 1999, 68 (03) :114-150
[5]
Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders [J].
Brown, ES ;
Rush, AJ ;
McEwen, BS .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (04) :474-484
[6]
Role of serotonin in memory impairment [J].
Buhot, HC ;
Martin, S ;
Segu, L .
ANNALS OF MEDICINE, 2000, 32 (03) :210-221
[7]
Checkley S, 1996, BRIT MED BULL, V52, P597
[8]
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice [J].
Cryan, JF ;
Mombereau, C .
MOLECULAR PSYCHIATRY, 2004, 9 (04) :326-357
[9]
Stress in the brain [J].
de Kloet, ER .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 405 (1-3) :187-198
[10]
Brain mineralocorticoid receptors and centrally regulated functions [J].
de Kloet, ER ;
van Acker, SABE ;
Sibug, RM ;
Oitzl, MS ;
Meijer, OC ;
Rahmouni, K ;
de Jong, W .
KIDNEY INTERNATIONAL, 2000, 57 (04) :1329-1336