共 16 条
Artificial enzymes made to order: Combination of computational design and directed evolution
被引:25
作者:

Ward, Thomas R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Basel, Dept Chem, CH-4056 Basel, Switzerland Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
机构:
[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
关键词:
artificial enzymes;
directed evolution;
elimination;
enzyme design;
proton transfer;
D O I:
10.1002/anie.200802865
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
引用
收藏
页码:7802 / 7803
页数:2
相关论文
共 16 条
[1]
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
[J].
Chica, RA
;
Doucet, N
;
Pelletier, JN
.
CURRENT OPINION IN BIOTECHNOLOGY,
2005, 16 (04)
:378-384

Chica, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

Doucet, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

Pelletier, JN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada
[2]
De novo protein design: Fully automated sequence selection
[J].
Dahiyat, BI
;
Mayo, SL
.
SCIENCE,
1997, 278 (5335)
:82-87

Dahiyat, BI
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH,HOWARD HUGHES MED INST,PASADENA,CA 91125

Mayo, SL
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH,HOWARD HUGHES MED INST,PASADENA,CA 91125
[3]
Structural origins of efficient proton abstraction from carbon by a catalytic antibody
[J].
Debler, EW
;
Ito, S
;
Seebeck, FP
;
Heine, A
;
Hilvert, D
;
Wilson, IA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (14)
:4984-4989

Debler, EW
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

Ito, S
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

Seebeck, FP
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

Heine, A
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

Hilvert, D
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

Wilson, IA
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[4]
Off-the-shelf proteins that rival tailor-made antibodies as catalysts
[J].
Hollfelder, F
;
Kirby, AJ
;
Tawfik, DS
.
NATURE,
1996, 383 (6595)
:60-63

Hollfelder, F
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

Kirby, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

Tawfik, DS
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND
[5]
De novo computational design of retro-aldol enzymes
[J].
Jiang, Lin
;
Althoff, Eric A.
;
Clemente, Fernando R.
;
Doyle, Lindsey
;
Rothlisberger, Daniela
;
Zanghellini, Alexandre
;
Gallaher, Jasmine L.
;
Betker, Jamie L.
;
Tanaka, Fujie
;
Barbas, Carlos F., III
;
Hilvert, Donald
;
Houk, Kendall N.
;
Stoddard, Barry L.
;
Baker, David
.
SCIENCE,
2008, 319 (5868)
:1387-1391

论文数: 引用数:
h-index:
机构:

Althoff, Eric A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Clemente, Fernando R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Doyle, Lindsey
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Rothlisberger, Daniela
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Zanghellini, Alexandre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
Univ Washington, Biomol Struct & Design Program, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Gallaher, Jasmine L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Betker, Jamie L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Tanaka, Fujie
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Barbas, Carlos F., III
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Hilvert, Donald
论文数: 0 引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Houk, Kendall N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Stoddard, Barry L.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA

论文数: 引用数:
h-index:
机构:
[6]
De novo design of catalytic proteins
[J].
Kaplan, J
;
DeGrado, WF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2004, 101 (32)
:11566-11570

Kaplan, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

DeGrado, WF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[7]
Design of a novel globular protein fold with atomic-level accuracy
[J].
Kuhlman, B
;
Dantas, G
;
Ireton, GC
;
Varani, G
;
Stoddard, BL
;
Baker, D
.
SCIENCE,
2003, 302 (5649)
:1364-1368

Kuhlman, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Dantas, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Ireton, GC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Varani, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Stoddard, BL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Biochem, Seattle, WA 98195 USA

Baker, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA
[8]
A GENETIC APPROACH TO THE GENERATION OF ANTIBODIES WITH ENHANCED CATALYTIC ACTIVITIES
[J].
LESLEY, SA
;
PATTEN, PA
;
SCHULTZ, PG
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1993, 90 (04)
:1160-1165

LESLEY, SA
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720 UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

PATTEN, PA
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720 UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

SCHULTZ, PG
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720 UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720
[9]
Bifunctional catalysis of proton transfer at an antibody active site
[J].
Mueller, Roger
;
Debler, Erik W.
;
Steinmann, Michael
;
Seebeck, Florian P.
;
Wilson, Ian A.
;
Hilvert, Donald
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2007, 129 (03)
:460-461

Mueller, Roger
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA

Debler, Erik W.
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA

Steinmann, Michael
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA

Seebeck, Florian P.
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA

Wilson, Ian A.
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA

Hilvert, Donald
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Skaggs Inst Chem Biol, Dept Mol Biol, La Jolla, CA 92037 USA
[10]
Design and evolution of new catalytic activity with an existing protein scaffold
[J].
Park, HS
;
Nam, SH
;
Lee, JK
;
Yoon, CN
;
Mannervik, B
;
Benkovic, SJ
;
Kim, HS
.
SCIENCE,
2006, 311 (5760)
:535-538

Park, HS
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Nam, SH
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Lee, JK
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Yoon, CN
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Mannervik, B
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Benkovic, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

Kim, HS
论文数: 0 引用数: 0
h-index: 0
机构: Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea