Roles of pancreatic polypeptide in regulation of food intake

被引:109
作者
Katsuura, G
Asakawa, A
Inui, A [1 ]
机构
[1] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis, Kobe, Hyogo 6500017, Japan
[2] Shionogi & Co Ltd, Aburahi Labs, Shiga 5203423, Japan
关键词
pancreatic polypeptide; food intake; gastric emptying;
D O I
10.1016/S0196-9781(01)00604-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand, central administration of PP elicits food intake and gastric emptying. Therefore, PP actions on food intake may be. in part, attributable to gastric emptying. PP transgenic mice exhibit decreases in both food intake and gastric emptying rate that were clearly reversed by anti-PP antiserum. PP is an anorexigenic signal in the periphery and anorexigenic signal in the central nervous system. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:323 / 329
页数:7
相关论文
共 69 条
[1]  
ADRIAN TE, 1977, LANCET, V1, P161
[2]  
ADRIAN TE, 1997, LANCET, V349, P161
[3]   Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice [J].
Asakawa, A ;
Inui, A ;
Ueno, N ;
Fujimiya, M ;
Fujino, MA ;
Kasuga, M .
PEPTIDES, 1999, 20 (12) :1445-1448
[4]   REGIONAL VARIATION IN TRANSPORT OF PANCREATIC-POLYPEPTIDE ACROSS THE BLOOD-BRAIN-BARRIER OF MICE [J].
BANKS, WA ;
KASTIN, AJ ;
JASPAN, JB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 51 (01) :139-147
[5]   CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN Y4 SUBTYPE RECEPTOR FOR PANCREATIC-POLYPEPTIDE, NEUROPEPTIDE-Y, AND PEPTIDE YY [J].
BARD, JA ;
WALKER, MW ;
BRANCHEK, TA ;
WEINSHANK, RL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26762-26765
[6]   PANCREATIC-POLYPEPTIDE INFUSIONS REDUCE FOOD-INTAKE IN PRADER-WILLI SYNDROME [J].
BERNTSON, GG ;
ZIPF, WB ;
ODORISIO, TM ;
HOFFMAN, JA ;
CHANCE, RE .
PEPTIDES, 1993, 14 (03) :497-503
[7]  
BHATTACHARYA S, 1994, SOC NEUR ABSTR, V20, P361
[8]   ARE PEPTIDES TRULY SATIETY AGENTS - A METHOD OF TESTING FOR NEUROHUMORAL SATIETY EFFECTS [J].
BILLINGTON, CJ ;
LEVINE, AS ;
MORLEY, JE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (06) :R920-R926
[9]  
Bray G. A., 1996, MOL GENETIC ASPECTS, P2
[10]   An explanation of hunger. [J].
Cannon, WB ;
Washburn, AL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1912, 29 (05) :441-454