Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

被引：347

作者：

Hu, Gangqing ^{[1
]}

Tang, Qingsong ^{[1
]}

Sharma, Suveena ^{[2
]}

Yu, Fang ^{[2
]}

Escobar, Thelma M. ^{[2
]}

Muljo, Stefan A. ^{[2
]}

Zhu, Jinfang ^{[2
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Syst Biol Ctr, NIH, Bethesda, MD 20892 USA

[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE IDENTIFICATION; TRANSCRIPTION FACTOR; INTEGRATIVE ANNOTATION; GENE-EXPRESSION; CUTTING EDGE; REVEALS; SEQUENCES; FEATURES; DOMAINS; TMEVPG1;

D O I：

10.1038/ni.2712

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for genes that encode proteins with immunoregulatory functions. Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the T(H)2 subset of helper T cells and was important for the migration of T(H)2 cells.

引用

页码：1190 / U118

页数：11

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