Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis

被引:97
作者
Buckee, Caroline O. [1 ]
Jolley, Keith A. [1 ]
Recker, Mario [1 ]
Penman, Bridget [1 ]
Kriz, Paula [2 ]
Gupta, Sunetra [1 ]
Maiden, Martin C. J. [1 ]
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] Natl Inst Publ Hlth, Natl Reference Lab Meningococcal Infect, Prague 10042, Czech Republic
基金
英国惠康基金;
关键词
bacteria; meningococcus; population structure; strain; mathematical model;
D O I
10.1073/pnas.0712019105
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of recombination. In addition, the propensity to cause invasive disease is associated with particular "hyperinvasive'' lineages that coexist with less invasive lineages despite the fact that disease does not contribute to host-to-host transmission. Here, by combining a modeling approach with molecular epidemiological data from 1,108 meningococci isolated in the Czech Republic over 27 years, we show that interstrain competition, mediated by immune selection, can explain both the persistence of multiple discrete meningococcal lineages and the association of a subset of these with invasive disease. The model indicates that the combinations of allelic variants of housekeeping genes that define these lineages are associated with very small differences in transmission efficiency among hosts. These findings have general implications for the emergence of lineage structure and virulence in recombining bacterial populations.
引用
收藏
页码:15082 / 15087
页数:6
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