Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

被引：62

作者：

Don, Aruni S. Arachchige ^{[1
]}

Tsang, Chi Kwan ^{[1
]}

Kazdoba, Tatiana M. ^{[2
]}

D'Arcangelo, Gabriella ^{[2
]}

Young, Wise ^{[3
]}

Zheng, X. F. Steven ^{[1
]}

机构：

[1] UMDNJ Robert Wood Johnson Med Sch RWJMS, Dept Pharmacol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Grad Program Neurosci, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 15-16期

关键词：

SPINAL-CORD-INJURY; BRAIN-INJURY; AXON REGENERATION; MAMMALIAN TARGET; NERVOUS-SYSTEM; RAPAMYCIN MTOR; SIGNALING PATHWAYS; CONTROLLED-TRIAL; CLINICAL-TRIALS; ADULT BRAIN;

D O I：

10.1016/j.drudis.2012.04.010

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The adult central nervous system (CNS) has a remarkable ability to repair itself. However, severe brain and spinal cord injuries (SCIs) cause lasting disability and there are only a few therapies that can prevent or restore function in such cases. In this review, we provide an overview of traumatic CNS injuries and discuss several emerging pharmacological options that have shown promise in preclinical and early clinical studies. We highlight therapies that modulate mammalian target of rapamycin (mTOR) signaling, a pathway that is well known for its roles in cell growth, metabolism and cancer. Interestingly, this pathway is also gaining newfound attention for its role in CNS repair and regeneration.

引用

页码：861 / 868

页数：8

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