Complex clonal features in an Mycobacterium tuberculosis infection in a two-year-old child

被引：19

作者：

Garcia de Viedma, Dario ^{[1
]}

Marín, Mercedes ^{[1
]}

Andrés, Sandra ^{[1
]}

Lorenzo, Gema ^{[1
]}

Ruiz-Serrano, Maria Jesus ^{[1
]}

Bouza, Emilio ^{[1
]}

机构：

[1] Hosp Gregorio Maranon, Serv Microbiol Clin & Enfermedades Infecc, Madrid, Spain

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2006年 / 25卷 / 05期

关键词：

tuberculosis; pediatric infection; microevolution; coinfection; molecular typing;

D O I：

10.1097/01.inf.0000217473.90673.00

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The focus of this report is to describe the highly complex clonal features of the Mycobacterium tuberculosis (MTB) isolates cultured from a 2-year-old child with no risk factors for tuberculosis. Molecular analysis showed that she was coinfected by 2 MTB isolates, The coinfecting isolates showed only subtle genetic differences and shared equivalent infectivity in vitro; however, they were infecting independent anatomic sites (compartmentalized infection). One of the MTB isolates was cultured only from respiratory specimens, whereas the other was isolated from extrarespiratory site (central nervous system).

引用

页码：457 / 459

页数：3

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