The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation

被引：216

作者：

Peng, Lily ^{[1
,2
]}

Eltgroth, Matthew L. ^{[1
,2
]}

LaTempa, Thomas J. ^{[3
,4
]}

Grimes, Craig A. ^{[3
,4
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA

[4] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

来源：

BIOMATERIALS | 2009年 / 30卷 / 07期

基金：

美国国家科学基金会;

关键词：

Endothelial cell; Vascular smooth musle cell; Nanotopography; CELL DIFFERENTIATION; ANODIZATION; ADHESION; SURFACES; ARRAYS; STENT;

D O I：

10.1016/j.biomaterials.2008.11.012

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this study we investigate the effects of nanotubular titanium oxide (TiO2) surfaces on vascular cells. EC and VSMC response to nanotubes was investigated through immunofluorescence staining, scanning electron microscopy. 5-ethynyl-2'-deoxytrridine proliferation assays, and prostaglandin I-2 (PGI(2)) enzyme immunoassays. We found that the nanotubular surface significantly enhances EC proliferation and secretion of PGI(2). The surface also results in a decrease in VSMC proliferation and increased expression of smooth muscle alpha-actin. These data suggest that engineered nanotopographical cues may influence both EC and VSMC behavior in a manner that may be useful for stent or other vascular applications. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1268 / 1272

页数：5

共 20 条

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