The role of peroxisome proliferator-activated receptor γ in bladder cancer in relation to angiogenesis and progression

被引:16
作者
Possati, L [1 ]
Rocchetti, R
Talevi, S
Beatrici, V
Margiotta, C
Ferrante, L
Calza, R
Sagrini, D
Ferri, A
机构
[1] Univ Ancona, Dept Biomed Sci, I-60131 Ancona, Italy
[2] Hosp Fano, Dept Surg, Urol Unit, Fano, Italy
[3] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy
来源
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 2000年 / 35卷 / 05期
关键词
D O I
10.1016/S0306-3623(01)00116-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Peroxisome proliferator-activated receptor gamma (PPARgamma) immunohistochemical expression was analyzed in 75 human bladder tumor specimens, where the expression of some angiogenic factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived endothelial cell growth factor (PDECGF), and tumor progression markers, such as epidermal growth factor receptor (EGFr), p16, mutated p53, and normal pRB, were also analyzed. The results were then compared to the clinical and pathological characteristics of the disease. PPARgamma was expressed more significantly in papillary tumors than in solid cancers, and its presence was associated with statistical significance to low incidence of tumor recurrence or progression. This significant association was observed also when PPARgamma was expressed in the presence of PDECGF, which resulted, when considered alone, to an angiogenic factor typical of solid cancers and appeared related to poor prognosis. In the presence of bFGF, on the contrary, PPARgamma expression no longer resulted to a significant association with low incidence of tumor recurrence or progression, suggesting a possible worsening role of this angiogenic factor, typical of papillary cancers, in its interaction with PPARgamma. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:269 / 275
页数:7
相关论文
共 20 条
[1]   Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Δ12,14-prostaglandin J2 [J].
Bishop-Bailey, D ;
Hla, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (24) :17042-17048
[2]   Differential activation of adipogenesis by multiple PPAR isoforms [J].
Brun, RP ;
Tontonoz, P ;
Forman, BM ;
Ellis, R ;
Chen, J ;
Evans, RM ;
Spiegelman, BM .
GENES & DEVELOPMENT, 1996, 10 (08) :974-984
[3]   The nuclear receptor PPARγ and immunoregulation:: PPARγ mediates inhibition of helper T cell responses [J].
Clark, RB ;
Bishop-Bailey, D ;
Estrada-Hernandez, T ;
Hla, T ;
Puddington, L ;
Padula, SJ .
JOURNAL OF IMMUNOLOGY, 2000, 164 (03) :1364-1371
[4]   15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR-GAMMA [J].
FORMAN, BM ;
TONTONOZ, P ;
CHEN, J ;
BRUN, RP ;
SPIEGELMAN, BM ;
EVANS, RM .
CELL, 1995, 83 (05) :803-812
[5]   Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans [J].
Guan, YF ;
Zhang, YH ;
Davis, L ;
Breyer, MD .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1997, 273 (06) :F1013-F1022
[6]  
Guan You-Fei, 1999, Neoplasia (New York), V1, P330, DOI 10.1038/sj.neo.7900050
[7]   Differential expression of the peroxisome proliferator-activated receptor γ (PPARγ) and its coactivators steroid receptor coactivator-1 and PPAR binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse [J].
Jain, S ;
Pulikuri, S ;
Zhu, YJ ;
Qi, C ;
Kanwar, YS ;
Yeldandi, AV ;
Rao, MS ;
Reddy, JK .
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (02) :349-354
[8]   Expression and function of PPARγ in rat and human vascular smooth muscle cells [J].
Law, RE ;
Goetze, S ;
Xi, XP ;
Jackson, S ;
Kawano, Y ;
Demer, L ;
Fishbein, MC ;
Meehan, WP ;
Hsueh, WA .
CIRCULATION, 2000, 101 (11) :1311-1318
[9]   Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice [J].
Lefebvre, AM ;
Chen, IH ;
Desreumaux, P ;
Najib, J ;
Fruchart, JC ;
Geboes, K ;
Briggs, M ;
Heyman, R ;
Auwerx, J .
NATURE MEDICINE, 1998, 4 (09) :1053-1057
[10]   AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH-AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA(PPAR-GAMMA) [J].
LEHMANN, JM ;
MOORE, LB ;
SMITHOLIVER, TA ;
WILKISON, WO ;
WILLSON, TM ;
KLIEWER, SA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :12953-12956