Vascular-platelet and plasma hemostasis regulators from bloodsucking animals

被引:28
作者
Basanova, AV
Baskova, IP [1 ]
Zavalova, LL
机构
[1] Moscow MV Lomonosov State Univ, Sch Biol, Moscow 119899, Russia
[2] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
关键词
bloodsuckers; leeches; insects; ticks; vascular-platelet hemostasis; platelet adhesion and aggregation; prothrombinase complex; factor Xa;
D O I
10.1023/A:1013968618120
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages, This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular-platelet hemostasis by blocking collagen-induced platelet adhesion/aggregation. Plasma hemostasis is inhibited by blocking activation of factor X or factor Xa directly.
引用
收藏
页码:143 / 150
页数:8
相关论文
共 67 条
[1]   Novel anticoagulant from salivary glands of Simulium vittatum (Diptera: Simuliidae) inhibits activity of coagulation factor V [J].
Abebe, M ;
Ribeiro, JMC ;
Cupp, MS ;
Cupp, EW .
JOURNAL OF MEDICAL ENTOMOLOGY, 1996, 33 (01) :173-176
[2]   ANTICOAGULANT ACTIVITY IN SALIVARY-GLAND EXTRACTS OF BLACK FLIES (DIPTERA, SIMULIIDAE) [J].
ABEBE, M ;
CUPP, MS ;
RAMBERG, FB ;
CUPP, EW .
JOURNAL OF MEDICAL ENTOMOLOGY, 1994, 31 (06) :908-911
[3]   The glycoprotein Ib-IX-V complex in platelet adhesion and signaling [J].
Andrews, RK ;
Shen, Y ;
Gardiner, EE ;
Dong, JF ;
López, JA ;
Berndt, MC .
THROMBOSIS AND HAEMOSTASIS, 1999, 82 (02) :357-364
[4]  
APITZCASTRO R, 1995, THROMB HAEMOSTASIS, V73, P94
[5]   Invertebrate compounds acting on the hemostatic mechanism [J].
Arocha-Piñango, CL ;
Marchi, R ;
Carvajal, Z ;
Guerrero, B .
BLOOD COAGULATION & FIBRINOLYSIS, 1999, 10 (02) :43-68
[6]  
Baskova I, 2000, PLATELETS, V11, P83, DOI 10.1080/09537100075689
[7]  
BASKOVA I P, 1984, Byulleten' Eksperimental'noi Biologii i Meditsiny, V97, P696
[8]  
BASKOVA I P, 1984, Byulleten' Eksperimental'noi Biologii i Meditsiny, V97, P142
[9]  
BASKOVA I P, 1988, Biokhimiya, V53, P1467
[10]  
BASKOVA I P, 1987, Biokhimiya, V52, P1461