Vascular-platelet and plasma hemostasis regulators from bloodsucking animals

被引：28

作者：

Basanova, AV

Baskova, IP ^{[1
]}

Zavalova, LL

机构：

[1] Moscow MV Lomonosov State Univ, Sch Biol, Moscow 119899, Russia

[2] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2002年 / 67卷 / 01期

关键词：

bloodsuckers; leeches; insects; ticks; vascular-platelet hemostasis; platelet adhesion and aggregation; prothrombinase complex; factor Xa;

D O I：

10.1023/A:1013968618120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages, This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular-platelet hemostasis by blocking collagen-induced platelet adhesion/aggregation. Plasma hemostasis is inhibited by blocking activation of factor X or factor Xa directly.

引用

页码：143 / 150

页数：8

共 67 条

[1] Novel anticoagulant from salivary glands of Simulium vittatum (Diptera: Simuliidae) inhibits activity of coagulation factor V [J].