Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

被引：72

作者：

Liu, Rong ^{[1
,2
,3
]}

Zhang, Zhuo ^{[1
,2
,3
]}

Lu, Zhengjuan ^{[1
,2
,3
]}

Borlongan, Cesar ^{[4
]}

Pan, Jie ^{[1
,2
,3
]}

Chen, Junhao ^{[3
]}

Qian, Lai ^{[1
,2
,3
]}

Liu, Zhuo ^{[1
,2
,3
]}

Zhu, Lin ^{[1
,2
,3
]}

Zhang, Jun ^{[5
]}

Xu, Yun ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ, Affiliated Drum Tower Hosp, Sch Med, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210008, Jiangsu, Peoples R China

[3] Jiangsu Key Lab Mol Med, Nanjing, Jiangsu, Peoples R China

[4] Univ S Florida, Dept Neurosurg & Brain Repair, Tampa, FL USA

[5] Jiangsu Prov Stem Cell Engn Res Ctr, Taizhou, Jiangsu, Peoples R China

来源：

STEM CELLS AND DEVELOPMENT | 2013年 / 22卷 / 07期

基金：

中国国家自然科学基金;

关键词：

MULTIPLE-SCLEROSIS; BONE-MARROW; EXPERIMENTAL STROKE; BRAIN INFLAMMATION; PRECURSOR CELLS; DIFFERENTIATION; LINGO-1; MICE; TRANSPLANTATION; EXPRESSION;

D O I：

10.1089/scd.2012.0463

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous system, in part influenced by chronic inflammation. There is no proven effective therapy to stop the pathological progression of MS, although suppressing the immune system to control the inflammatory response may improve the clinical performance acutely. Here, we found that mesenchymal stem cells from human umbilical cord (hUC-MSCs) could restore behavioral functions and attenuate the histopathological deficits of experimental autoimmune encephalomyelitis mice over the long term (ie, 50 days) by suppression of perivascular immune cell infiltrations and reduction in both demyelination and axonal injury in the spinal cord. These findings suggest that transplantation of hUC-MSCs may be a potential therapy for MS.

引用

页码：1053 / 1062

页数：10

共 29 条

[1] Human Bone Marrow-Derived Mesenchymal Stem Cells Induce Th2-Polarized Immune Response and Promote Endogenous Repair in Animal Models of Multiple Sclerosis [J].

Bai, Lianhua ;

Lennon, Donald P. ;

Eaton, Valerie ;

Maier, Kari ;

Caplan, Arnold I. ;

Miller, Stephen D. ;

Miller, Robert H. .

GLIA, 2009, 57 (11) :1192-1203

[2] Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow [J].

Baksh, Dolores ;

Yao, Raphael ;

Tuan, Rocky S. .

STEM CELLS, 2007, 25 (06) :1384-1392

[3] Exogenous IL-12 suppresses experimental autoimmune encephalomyelitis (EAE) by tuning IL-10 and IL-5 levels in an IFN-γ-dependent way [J].

Berghmans, Nele ;

Dillen, Chris ;

Heremans, Hubertine .

JOURNAL OF NEUROIMMUNOLOGY, 2006, 176 (1-2) :63-75

[4]

Beyer Nardi N, 2006, HANDB EXP PHARM, V174, P249

[5] Cocaine-and amphetamine-regulated transcript modulates peripheral immunity and protects against brain injury in experimental stroke [J].

Chang, Leilei ;

Chen, Yanting ;

Li, Jie ;

Liu, Zhuo ;

Wang, Zhongyuan ;

Chen, Junhao ;

Cao, Wangsen ;

Xu, Yun .

BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (02) :260-269

[6] Endothelial differentiation of Wharton's jelly-derived mesenchymal stem cells in comparison with bone marrow-derived mesenchymal stem cells [J].

Chen, Ming-Yan ;

Lie, Pu-Chang ;

Li, Zhi-Ling ;

Wei, Xing .

EXPERIMENTAL HEMATOLOGY, 2009, 37 (05) :629-640

[7] Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis [J].

Constantin, Gabriela ;

Marconi, Silvia ;

Rossi, Barbara ;

Angiari, Stefano ;

Calderan, Laura ;

Anghileri, Elena ;

Gini, Beatrice ;

Bach, Simone Dorothea ;

Martinello, Marianna ;

Bifari, Francesco ;

Galie, Mirco ;

Turano, Ermanna ;

Budui, Simona ;

Sbarbati, Andrea ;

Krampera, Mauro ;

Bonetti, Bruno .

STEM CELLS, 2009, 27 (10) :2624-2635

[8] Widespread electroanatomic alterations of right cardiac chambers in patients with myotonic dystrophy type 1 [J].

Dello Russo, A ;

Pelargonio, G ;

Parisi, Q ;

Santamaria, M ;

Messano, L ;

Sanna, T ;

Casella, M ;

De Martino, G ;

De Ponti, R ;

Pace, M ;

Giglio, V ;

Ierardi, C ;

Zecchi, P ;

Crea, F ;

Bellocci, F .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2006, 17 (01) :34-40

[9] Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells [J].

Deuse, Tobias ;

Stubbendorff, Mandy ;

Tang-Quan, Karis ;

Phillips, Neil ;

Kay, Mark A. ;

Eiermann, Thomas ;

Phan, Thang T. ;

Volk, Hans-Dieter ;

Reichenspurner, Hermann ;

Robbins, Robert C. ;

Schrepfer, Sonja .

CELL TRANSPLANTATION, 2011, 20 (05) :655-667

[10] Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis [J].

Einstein, O ;

Grigoriadis, N ;

Mizrachi-Kol, R ;

Reinhartz, E ;

Polyzoidou, E ;

Lavon, I ;

Milonas, I ;

Karussis, D ;

Abramsky, O ;

Ben-Hur, T .

EXPERIMENTAL NEUROLOGY, 2006, 198 (02) :275-284

← 1 2 3 →