Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults

被引:125
作者
Gunstad, John [1 ,3 ]
Benitez, Andreana [1 ]
Smith, Joseph [1 ]
Glickman, Ellen [2 ]
Spitznagel, Mary B. [1 ,3 ]
Alexander, Thomas [4 ]
Juvancic-Heltzel, Judi [2 ]
Murray, Leigh [5 ]
机构
[1] Kent State Univ, Dept Psychol, Kent, OH 44242 USA
[2] Kent State Univ, Sch Exercise Leisure & Sport, Exercise Sci Lab, Kent, OH 44242 USA
[3] Summa Hlth Syst, Dept Psychiat, Ctr Neuropsychol Studies, Akron, OH USA
[4] Summa Hlth Syst, Dept Pathol, Akron, OH USA
[5] Walsh Univ, Dept Phys Therapy, N Canton, OH USA
关键词
cognition; brain-derived neurotrophic factor; elderly;
D O I
10.1177/0891988708316860
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 [法学]; 0303 [社会学]; 100203 [老年医学];
摘要
Cognitive decline is common in older adults, even in the absence of significant medical or neurological conditions. Recent work implicates serum levels of brain-derived neurotrophic factor in age-related cognitive decline, though 110 Study has directly examined this possibility A total of 35 older adults without neurological history underwent fasting blood draw and completed a brief neuropsychological test battery during a single session. After adjusting for demographic and medical confounds, higher serum brain-derived neurotrophic factor levels were associated with better performance on the Mini-Mental State Examination (r = .36) and short form of the Boston Naming Test (r = .39). These findings extend work from Alzheimer disease and vasuclar dementia samples and indicate that higher brain-derived neurotrophic factor levels are associated with better neuropsychological function in healthy older adults. The exact mechanisms for this relationship are unknown and require further examination.
引用
收藏
页码:166 / 170
页数:5
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