ATP-citrate lyase: A mini-review

被引：220

作者：

Chypre, Melanie ^{[1
]}

Zaidi, Nousheen ^{[1
,2
]}

Smans, Karine ^{[1
]}

机构：

[1] Janssen Res & Dev, Dept Oncol, B-2340 Beerse, Belgium

[2] Katholieke Univ Leuven, Lab Lipid Metab & Canc, Dept Oncol, Fac Med, Louvain, Belgium

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 422卷 / 01期

关键词：

ATP-citrate lyase; de novo lipid synthesis; Fatty acid synthesis; Mevalonate pathway; RAT-LIVER; LIPOGENIC ENZYMES; CELL-GROWTH; CANCER; PHOSPHORYLATION; IDENTIFICATION; PURIFICATION; DEFICIENCY; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.bbrc.2012.04.144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. Acetyl-CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. Acetyl-CoA is also required for acetylation reactions that modify proteins such as histone acetylation. In the present review some of the known features of ACLY such as tissue distribution, subcellular localization, enzymatic properties, gene regulation and associated physiological conditions are highlighted. (C) 2012. Elsevier Inc. All rights reserved.

引用

页码：1 / 4

页数：4

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