IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men

被引：270

作者：

Jouanguy, E ^{[1
]}

Döffinger, R ^{[1
]}

Dupuis, S ^{[1
]}

Pallier, A ^{[1
]}

Altare, F ^{[1
]}

Casanova, JL ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, Unite 429, F-75015 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80055-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-gamma in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to,IFN-gamma is the common : pathogenic mechanism that accounts for impaired granuloma formation and uncontrolled growth of bacteria within macrophages. The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men.

引用

页码：346 / 351

页数：6

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