Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice

被引：164

作者：

Takagi, Y ^{[1
]}

Nozaki, K

Takahashi, J

Yodoi, J

Ishikawa, M

Hashimoto, N

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Sakyo Ku, Kyoto, Japan

[2] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Sakyo Ku, Kyoto, Japan

[3] Kitano Hosp, Inst Med, Dept Neurosurg, Kita Ku, Osaka, Japan

来源：

BRAIN RESEARCH | 1999年 / 831卷 / 1-2期

关键词：

neurogenesis; transient forebrain ischemia; 5-bromodeoxyuridine; dentate gyrus;

D O I：

10.1016/S0006-8993(99)01411-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the proliferation of neuronal progenitor cells by labeling dividing cells by systemic application of the thymidine analog 5-bromodeoxyuridine (BrdU) during transient forebrain ischemia in mice. At 3 (n = 6), 7 (n = 6), 10(n = 6), and 17 days (n = 6) after reperfusion, BrdU-labeled cells were detected in the dentate gyrus and paraventricle lesion, After ischcmia-reperfusion, BrdU-labeled cells in the dentate gyrus significantly increased in number but not in the paraventricle lesion. These observations may help to clarify the mechanism of functional recovery after stroke. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：283 / 287

页数：5

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