OPINION Epigenome dynamics: a quantitative genetics perspective

被引：154

作者：

Johannes, Frank ^{[1
]}

Colot, Vincent ^{[2
]}

Jansen, Ritsert C. ^{[1
,3
]}

机构：

[1] Univ Groningen, Groningen Bioinformat Ctr, NL-9751 NN Haren, Netherlands

[2] Ecole Normale Super, Dept Biol, Natl Ctr Sci Res, UMR8186, F-75230 Paris 05, France

[3] Univ Groningen, Med Ctr, Dept Genet, NL-9700 RB Groningen, Netherlands

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 11期

关键词：

D O I：

10.1038/nrg2467

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread epigenetic variation in natural and experimental populations. Here we argue that it is timely to consider novel experimental strategies and analysis models to capture the potentially dynamic interplay between chromatin and DNA sequence factors in complex traits.

引用

页码：883 / 890

页数：8

共 50 条

[1] An integrated epigenetic and genetic approach to common human disease [J].

Bjornsson, HT ;

Fallin, MD ;

Feinberg, AP .

TRENDS IN GENETICS, 2004, 20 (08) :350-358

[2] Epigenetics for ecologists [J].

Bossdorf, Oliver ;

Richards, Christina L. ;

Pigliucci, Massimo .

ECOLOGY LETTERS, 2008, 11 (02) :106-115

[3] Gardening the genome:: DNA methylation in Arabidopsis thaliana [J].

Chan, SWL ;

Henderson, IR ;

Jacobsen, SE .

NATURE REVIEWS GENETICS, 2005, 6 (05) :351-360

[4]

Cheverud JM, 1996, GENETICS, V142, P1305

[5] Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning [J].

Cokus, Shawn J. ;

Feng, Suhua ;

Zhang, Xiaoyu ;

Chen, Zugen ;

Merriman, Barry ;

Haudenschild, Christian D. ;

Pradhan, Sriharsa ;

Nelson, Stanley F. ;

Pellegrini, Matteo ;

Jacobsen, Steven E. .

NATURE, 2008, 452 (7184) :215-219

[6]

CSABA P, 1998, P ROY SOC LOND B BIO, V265, P1319

[7]

DAS OP, 1994, GENETICS, V136, P1121

[8] Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes [J].

Farthing, Cassandra R. ;

Ficz, Gabriella ;

Ng, Ray Kit ;

Chan, Chun-Fung ;

Andrews, Simon ;

Dean, Wendy ;

Hemberger, Myriam ;

Reik, Wolf .

PLOS GENETICS, 2008, 4 (06)

[9] Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines [J].

Henckaerts, E ;

Geiger, H ;

Langer, JC ;

Rebollo, P ;

Van Zant, G ;

Snoeck, HW .

BLOOD, 2002, 99 (11) :3947-3954

[10] Epigenetic inheritance in plants [J].

Henderson, Ian R. ;

Jacobsen, Steven E. .

NATURE, 2007, 447 (7143) :418-424

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