An Opportunistic Infection Associated With Ruxolitinib, a Novel Janus Kinase 1,2 Inhibitor

被引：87

作者：

Wysham, Nicholas G. ^{[1
]}

Sullivan, Donald R. ^{[2
]}

Allada, Gopal ^{[2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Internal Med, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Pulm & Crit Care Med, Portland, OR 97239 USA

来源：

CHEST | 2013年 / 143卷 / 05期

关键词：

D O I：

10.1378/chest.12-1604

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

We report a case of Cryptococcus neoformans pneumonia in a patient taking ruxolitinib, a janus kinase 1,2 inhibitor approved for the treatment of myelofibrosis. We hypothesize that ruxolitinib contributed to this infection through its effects on cell-mediated immunity. Clinicians should be aware of the potential for intracellular or opportunistic infections associated with this novel drug class.

引用

页码：1478 / 1479

页数：2

共 6 条

[1]

Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis [J].

Garber, Ken .

NATURE BIOTECHNOLOGY, 2011, 29 (06) :467-468

[2]

Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry [J].

Salmon-Ceron, D. ;

Tubach, F. ;

Lortholary, O. ;

Chosidow, O. ;

Bretagne, S. ;

Nicolas, N. ;

Cuillerier, E. ;

Fautrel, B. ;

Michelet, C. ;

Morel, J. ;

Puechal, X. ;

Wendling, D. ;

Lemann, M. ;

Ravaud, P. ;

Mariette, X. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (04) :616-623

[3]

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis [J].

Sandborn, William J. ;

Ghosh, Subrata ;

Panes, Julian ;

Vranic, Ivana ;

Su, Chinyu ;

Rousell, Samantha ;

Niezychowski, Wojciech .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (07) :616-624

[4]

Challenges Facing JAK Inhibitor Therapy for Myeloproliferative Neoplasms [J].

Tefferi, Ayalew .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (09) :844-846

[5]

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis [J].

Verstovsek, Srdan ;

Mesa, Ruben A. ;

Gotlib, Jason ;

Levy, Richard S. ;

Gupta, Vikas ;

DiPersio, John F. ;

Catalano, John V. ;

Deininger, Michael ;

Miller, Carole ;

Silver, Richard T. ;

Talpaz, Moshe ;

Winton, Elliott F. ;

Harvey, Jimmie H., Jr. ;

Arcasoy, Murat O. ;

Hexner, Elizabeth ;

Lyons, Roger M. ;

Paquette, Ronald ;

Raza, Azra ;

Vaddi, Kris ;

Erickson-Viitanen, Susan ;

Koumenis, Iphigenia L. ;

Sun, William ;

Sandor, Victor ;

Kantarjian, Hagop M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (09) :799-807

[6]

Cryptococcal Interactions with the Host Immune System [J].

Voelz, Kerstin ;

May, Robin C. .

EUKARYOTIC CELL, 2010, 9 (06) :835-846

← 1 →