A new bioactive aminophenoxazinone alkaloid from a marine-derived actinomycete

被引：18

作者：

Abdelfattah, Mohamed S. ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 22期

关键词：

aminophenoxazinone; maroxazinone; actinomycete; spectroscopy; cytotoxic activity; STRUCTURE ELUCIDATION; BIOLOGICAL-ACTIVITY; PHENOXAZINE; DERIVATIVES; METABOLITES; ACID;

D O I：

10.1080/14786419.2013.793686

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation of the marine Streptomyces sp. Eg25 led to the isolation of one new natural 2-aminophenoxazin-3-one-8-carboxylic acid methyl ester named maroxazinone (1) as well as the known compounds elloxazinone A (2), exfoliazone (3), carboxyexfoliazone (4), elloxazinone B (5) and venezueline D (6). The chemical structures of the isolated compounds were deduced from extensive studies of NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC and HMBC) and mass spectra. The cytotoxic activities of the new maroxazinone (1) and venezueline D (6) against breast carcinoma cell line (MCF7), liver carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) were investigated.

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收藏

页码：2126 / 2131

页数：6

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