Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer

被引：220

作者：

Bauskin, Asne R.

Brown, David A.

Kuffner, Tamara

Johnen, Heiko

Luo, X. Wei

Hunter, Mark

Breit, Samuel N. ^{[1
]}

机构：

[1] St Vincents Hosp, Ctr Immunol, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Sydney, NSW, Australia

来源：

CANCER RESEARCH | 2006年 / 66卷 / 10期

关键词：

D O I：

10.1158/0008-5472.CAN-05-4067

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.

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收藏

页码：4983 / 4986

页数：4

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