Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice

被引：24

作者：

Van Dien, M

Takahashi, K

Mu, MM

Koide, N

Sugiyama, T

Mori, I

Yoshida, T

Yokochi, T ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Microbiol & Immunol, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ, Sch Med, Div Bacterial Toxin, Res Ctr Infect Dis, Nagakute, Aichi 4801195, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2001年 / 45卷 / 11期

关键词：

wogonin; endotoxin; tumor-necrosis factor; endotoxic shock;

D O I：

10.1111/j.1348-0421.2001.tb01311.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GaIN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-alpha. The reduction was more marked in mice injected with D-GaIN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GaIN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-a and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GaIN and LPS is discussed.

引用

页码：751 / 756

页数：6

共 27 条

[1] Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide [J].