Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice

被引：24

作者：

Ahmad, S ^{[1
]}

Anderson, WL ^{[1
]}

Kitchin, KT ^{[1
]}

机构：

[1] US EPA, Natl Hlth & Environm Effects Res Lab, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA

来源：

CANCER LETTERS | 1999年 / 139卷 / 02期

关键词：

dimethylarsinic acid; DNA damage; oxidative stress; B6C3F1; mice;

D O I：

10.1016/S0304-3835(99)00022-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19-59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：129 / 135

页数：7

共 45 条

[1] ANDERSSON L, 1985, ANIM BLOOD GROUPS BI, V16, P1
[2] Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells
Barchowsky, A
Dudek, EJ
Treadwell, MD
Wetterharn, KE
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1996, 21 (06) : 783 - 790
[3] ARSENIC INGESTION AND INTERNAL CANCERS - A REVIEW
BATES, MN
SMITH, AH
HOPENHAYNRICH, C
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 135 (05) : 462 - 476
[4] Brown JL, 1996, CANCER LETT, V98, P227
[5] Brown JL, 1997, TERATOGEN CARCIN MUT, V17, P71, DOI 10.1002/(SICI)1520-6866(1997)17:2<71::AID-TCM3>3.3.CO
[6] 2-X
[7] REDUCTION AND BINDING OF ARSENATE AND DIMETHYLARSINATE BY GLUTATHIONE - A MAGNETIC-RESONANCE STUDY
DELNOMDEDIEU, M
BASTI, MM
OTVOS, JD
THOMAS, DJ
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1994, 90 (02) : 139 - 155
[8] TIME-DEPENDENCE OF ACCUMULATION AND BINDING OF INORGANIC AND ORGANIC ARSENIC SPECIES IN RABBIT ERYTHROCYTES
DELNOMDEDIEU, M
STYBLO, M
THOMAS, DJ
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1995, 98 (01) : 69 - 83
[9] ARSENIC-INDUCED DNA-STRAND BREAKS ASSOCIATED WITH DNA-PROTEIN CROSS-LINKS IN HUMAN FETAL LUNG FIBROBLASTS
DONG, JT
LUO, XM
[J]. MUTATION RESEARCH, 1993, 302 (02): : 97 - 102
[10] REGULATION OF FERRITIN AND HEME OXYGENASE SYNTHESIS IN RAT FIBROBLASTS BY DIFFERENT FORMS OF IRON
EISENSTEIN, RS
GARCIAMAYOL, D
PETTINGELL, W
MUNRO, HN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) : 688 - 692

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