β-Cell Mass and Turnover in Humans Effects of obesity and aging

被引：310

作者：

Saisho, Yoshifumi ^{[1
]}

Butler, Alexandra E. ^{[1
]}

Manesso, Erica ^{[1
]}

Elashoff, David ^{[2
]}

Rizza, Robert A. ^{[3
]}

Butler, Peter C. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Larry L Hillblom Islet Res Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Stat Core, Los Angeles, CA 90095 USA

[3] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN USA

来源：

DIABETES CARE | 2013年 / 36卷 / 01期

基金：

美国国家卫生研究院;

关键词：

TYPE-2; DIABETES-MELLITUS; INSULIN-RESISTANCE; APOPTOSIS; REPLICATION; EXPANSION; SECRETION;

D O I：

10.2337/dc12-0421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-We sought to establish beta-cell mass, beta-cell apoptosis, and beta-cell replication in humans in response to obesity and advanced age. RESEARCH DESIGN ANDMETHODS-We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on beta-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. RESULTS-beta-Cell mass is increased by similar to 50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but beta-cell mass is remarkably preserved. There is minimal beta-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age. CONCLUSIONS-beta-Cell mass in human obesity increases by similar to 50% by an increase in beta-cell number, the source of which is unknown. beta-Cell mass is well preserved in humans with advanced aging. Diabetes Care 36: 111-117, 2013

引用

页码：111 / 117

页数：7

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