The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis

被引：99

作者：

Dang, ZC ^{[1
]}

Löwik, CWGM ^{[1
]}

机构：

[1] Leiden Univ, Ctr Med, Dept Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

osteoprogenitor cells; osteoblast; adipocyte; soy phytoestrogens; genistein;

D O I：

10.1359/JBMR.040120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The soy phytoestrogen daidzein has biphasic dose responses, but the underlying mechanisms are not yet clear. Transcriptional and biochemical data show that PPARs, in addition to ERs, are molecular targets of daidzein, which divergently regulates osteogenesis and adipogenesis. Dose responses are the result of a balance among PPARs and between ERs and PPARs.

引用

页码：853 / 861

页数：9

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