Potential peptide carriers:: Amphipathic proline-rich peptides derived from the n-terminal domain of γ-zein

被引：143

作者：

Fernández-Carneado, J

Kogan, MJ

Castel, S

Giralt, E

机构：

[1] Parc Cientif Barcelona, Inst Rec Biomed, E-08028 Barcelona, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

[3] SCT Univ Barcelona, Microscopia Confocal & Manipulacio Cellular, E-08028 Barcelona, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 14期

关键词：

amphipathicity; drug delivery; fluorescent probes; pepticles; solid-phase synthesis;

D O I：

10.1002/anie.200352540

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Breaking into cells: A new family of peptides based on the amphiphatic proline-rich sequence (VXLPPP)n, where n=1-3 and X= His, Lys, or Arg, has been designed (see picture). Their nonviral origin, absence of toxicity at high concentrations, and high solubility in water makes this new series very promising for use in drug delivery.

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页码：1811 / 1814

页数：4

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