The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors

被引：36

作者：

Parkin, NT ^{[1
]}

Gupta, S ^{[1
]}

Chappey, C ^{[1
]}

Petropoulos, CJ ^{[1
]}

机构：

[1] Monogram Biosci Inc, San Francisco, CA 94080 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1128/AAC.50.1.351-354.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n > 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n = 35) or a combination of K103R and V179D (n = 41). Site-directed mutagenesis confirmed the importance of these mutations.

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页码：351 / 354

页数：4

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