Practical total synthesis of (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol, the antitumorial and immunostimulatory alpha-galactosylceramide, KRN7000

被引：49

作者：

Morita, M ^{[1
]}

Sawa, E ^{[1
]}

Yamaji, K ^{[1
]}

Sakai, T ^{[1
]}

Natori, T ^{[1
]}

Koezuka, Y ^{[1
]}

Fukushima, H ^{[1
]}

Akimoto, K ^{[1
]}

机构：

[1] KIRIN BREWERY CO LTD, PHARMACEUT RES LAB, TAKASAKI, GUMMA 37012, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 02期

关键词：

KRN7000; agelasphins; alpha-galactosylceramide; practical total synthesis; D-lyxose;

D O I：

10.1271/bbb.60.288

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A practical total synthesis of (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol (KRN7000), an antitumorial and immunostimulatory glycosphingolipid derived from agelasphins, was achieved in 14 steps starting from D-lyxose in a 16% overall yield.

引用

页码：288 / 292

页数：5

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