Whole-body MRI for the detection of bone marrow involvement in lymphoma: prospective study in 116 patients and comparison with FDG-PET

被引:46
作者
Adams, Hugo J. A. [1 ]
Kwee, Thomas C. [1 ]
Vermoolen, Malou A. [1 ]
de Keizer, Bart [1 ]
de Klerk, John M. H. [2 ]
Adam, Judit A. [3 ]
Fijnheer, Rob [4 ]
Kersten, Marie Jose [5 ]
Stoker, Jaap [6 ]
Nievelstein, Rutger A. J. [1 ]
机构
[1] Univ Med Ctr Utrecht, Dept Radiol & Nucl Med, NL-3584 CX Utrecht, Netherlands
[2] Meander Med Ctr, Dept Nucl Med, Amersfoort, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands
[4] Meander Med Ctr, Dept Hematol, Amersfoort, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands
关键词
Bone marrow; FDG-PET; Hodgkin; Lymphoma; Whole-body MRI; POSITRON-EMISSION-TOMOGRAPHY; INFILTRATION; BIOPSY;
D O I
10.1007/s00330-013-2835-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
To assess and compare the value of whole-body MRI with FDG-PET for detecting bone marrow involvement in lymphoma. A total of 116 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI and blind bone marrow biopsy (BMB) of the posterior iliac crest. Of 116 patients, 80 also underwent FDG-PET. Patient-based sensitivities of whole-body MRI for detecting bone marrow involvement were calculated using BMB as reference standard and compared with FDG-PET in aggressive and indolent lymphomas separately. Sensitivity of whole-body MRI in all lymphomas was 45.5 % [95 % confidence interval (CI): 29.8-62.0 %]. Sensitivity of whole-body MRI in aggressive lymphoma [88.9 % (95 % CI: 54.3-100 %)] was significantly higher (P = 0.0029) than that in indolent lymphoma [23.5 % (95 % CI: 9.1-47.8 %)]. Sensitivity of FDG-PET in aggressive lymphoma [83.3 % (95 % CI: 41.8-98.9 %)] was also significantly higher (P = 0.026) than that in indolent lymphoma [12.5 % (95 % CI: 0-49.2 %)]. There were no significant differences in sensitivity between whole-body MRI and FDG-PET (P = 1.00) Sensitivity of whole-body MRI for detecting lymphomatous bone marrow involvement is too low to (partially) replace BMB. Sensitivity of whole-body MRI is significantly higher in aggressive lymphoma than in indolent lymphoma and is equal to FDG-PET in both entities.
引用
收藏
页码:2271 / 2278
页数:8
相关论文
共 28 条
[1]
Staging non-Hodgkin lymphoma [J].
Armitage, JO .
CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (06) :368-376
[2]
Bain BJ, 2006, HAEMATOLOGICA, V91, P1293
[3]
Is bone marrow biopsy obligatory in all patients with non-Hodgkin's lymphoma? [J].
Bairey, Osnat ;
Shpilberg, Ofer .
ACTA HAEMATOLOGICA, 2007, 118 (01) :61-64
[4]
Evolving concept of imaging bone marrow metastasis in the twenty-first century: critical role of FDG-PET [J].
Basu, Sandip ;
Torigian, Drew ;
Alavi, Abass .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (03) :465-471
[5]
A comparison of whole-body MRI and CT for the staging of lymphoma [J].
Brennan, DD ;
Gleeson, T ;
Coate, LE ;
Cronin, C ;
Carney, D ;
Eustace, SJ .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2005, 185 (03) :711-716
[6]
BILATERAL TREPHINE BONE-MARROW BIOPSIES IN LYMPHOMA AND OTHER NEOPLASTIC DISEASES [J].
BRUNNING, RD ;
BLOOMFIELD, CD ;
MCKENNA, RW ;
PETERSON, L .
ANNALS OF INTERNAL MEDICINE, 1975, 82 (03) :365-366
[7]
F-18 FDG PET for Evaluation of Bone Marrow Involvement in Non-Hodgkin Lymphoma A Meta-analysis [J].
Chen, Yen-Kung ;
Yeh, Chia-Lu ;
Tsui, Chih-Cheng ;
Liang, Ji-An ;
Chen, Jin-Hua ;
Kao, Chia-Hung .
CLINICAL NUCLEAR MEDICINE, 2011, 36 (07) :553-559
[8]
FREQUENCIES AND PATTERNS OF BONE-MARROW INVOLVEMENT IN NON-HODGKIN LYMPHOMAS - OBSERVATIONS ON VALUE OF BILATERAL BIOPSIES [J].
COLLER, BS ;
CHABNER, BA ;
GRALNICK, HR .
AMERICAN JOURNAL OF HEMATOLOGY, 1977, 3 :105-119
[9]
State-of-the-art therapeutics: Hodgkin's lymphoma [J].
Connors, JM .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (26) :6400-6408
[10]
Expert Opinions on Positron Emission Tomography and Computed Tomography Imaging in Lymphoma [J].
Delbeke, Dominique ;
Stroobants, Sigrid ;
de Kerviler, Eric ;
Gisselbrecht, Christian ;
Meignan, Michel ;
Conti, Peter S. .
ONCOLOGIST, 2009, 14 :30-40