Prediction of MEF2A-DNA interface by rigid body docking: A tool for fast estimation of protein mutational effects on DNA binding

被引：25

作者：

Fanelli, F

Ferrari, S

机构：

[1] Univ Modena & Reggio Emilia, Dept Chem, Modena, Italy

[2] Univ Modena & Reggio Emilia, Dulbecco Telethon Inst, Modena, Italy

[3] Univ Modena & Reggio Emilia, Dept Biomed Sci, Modena, Italy

来源：

JOURNAL OF STRUCTURAL BIOLOGY | 2006年 / 153卷 / 03期

关键词：

Protein-DNA docking; ZDOCK; MEF2A-DNA binding; computational modeling;

D O I：

10.1016/j.jsb.2005.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein-protein docking algorithm ZDOCK has been challenged for the first time to predict protein-DNA contacts. The computational approach defined in this study has proven effectiveness in fast in silico estimations of mutational effects of the MEF2A transcription factor on DNA binding. (C) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：278 / 283

页数：6

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