Implications of intratumour heterogeneity for treatment stratification

被引：48

作者：

Crockford, Andrew ^{[1
]}

Jamal-Hanjani, Mariam ^{[1
,2
]}

Hicks, James ^{[3
]}

Swanton, Charles ^{[1
,2
]}

机构：

[1] Canc Res UK London Res Inst, Translat Canc Therapeut Lab, London WC2A 3LY, England

[2] UCL Canc Inst, London WC1E 6BT, England

[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

JOURNAL OF PATHOLOGY | 2014年 / 232卷 / 02期

关键词：

intratumour heterogeneity; patient-derived xenograft models; personalized medicine; CIRCULATING TUMOR-CELLS; HER2 GENE AMPLIFICATION; FACTOR RECEPTOR 2; BREAST-CANCER; LUNG-CANCER; CLONAL EVOLUTION; CHROMOSOMAL INSTABILITY; SOLID TUMORS; IN-VITRO; RESISTANCE;

D O I：

10.1002/path.4270

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite advances in the diagnosis and treatment of cancer, the majority of advanced metastatic solid tumours remain incurable. Differential gene expression, somatic mutational status, tumour-specific genetic signatures and micro-environmental selection pressures within individual tumours have implications for the success of predictive assays to guide therapeutic intervention. In this review we discuss the evidence for genetic and phenotypic heterogeneity and its potential implications for clinical decision making. We highlight areas of research that could be improved in order to better stratify patient treatment. We also discuss the predictive potential of patient-derived models of tumour response, including xenograft and cell line-based systems within the context of intratumour heterogeneity. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：264 / 273

页数：10

共 88 条

[1]

Deciphering Signatures of Mutational Processes Operative in Human Cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Campbell, Peter J. ;

Stratton, Michael R. .

CELL REPORTS, 2013, 3 (01) :246-259

[2]

Genetic variegation of clonal architecture and propagating cells in leukaemia [J].

Anderson, Kristina ;

Lutz, Christoph ;

van Delft, Frederik W. ;

Bateman, Caroline M. ;

Guo, Yanping ;

Colman, Susan M. ;

Kempski, Helena ;

Moorman, Anthony V. ;

Titley, Ian ;

Swansbury, John ;

Kearney, Lyndal ;

Enver, Tariq ;

Greaves, Mel .

NATURE, 2011, 469 (7330) :356-+

[3]

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas [J].

Anglesio, Michael S. ;

Kommoss, Stefan ;

Tolcher, Mary C. ;

Clarke, Blaise ;

Galletta, Laura ;

Porter, Henry ;

Damaraju, Sambasivarao ;

Fereday, Sian ;

Winterhoff, Boris J. ;

Kalloger, Steve E. ;

Senz, Janine ;

Yang, Winnie ;

Steed, Helen ;

Allo, Ghassan ;

Ferguson, Sarah ;

Shaw, Patricia ;

Teoman, Attila ;

Garcia, Joaquin J. ;

Schoolmeester, John K. ;

Bakkum-Gamez, Jamie ;

Tinker, Anna V. ;

Bowtell, David D. ;

Huntsman, David G. ;

Gilks, C. Blake ;

McAlpine, Jessica N. .

JOURNAL OF PATHOLOGY, 2013, 229 (01) :111-120

[4]

[Anonymous], 2013, PLOS ONE

[5]

Prevalence and Heterogeneity of KRAS, BRAF, and PIK3CA Mutations in Primary Colorectal Adenocarcinomas and Their Corresponding Metastases [J].

Baldus, Stephan E. ;

Schaefer, Karl-L. ;

Engers, Rainer ;

Hartleb, Dinah ;

Stoecklein, Nikolas H. ;

Gabbert, Helmut E. .

CLINICAL CANCER RESEARCH, 2010, 16 (03) :790-799

[6]

BARRANCO SC, 1972, CANCER RES, V32, P2733

[7]

Replication stress links structural and numerical cancer chromosomal instability [J].

Burrell, Rebecca A. ;

McClelland, Sarah E. ;

Endesfelder, David ;

Groth, Petra ;

Weller, Marie-Christine ;

Shaikh, Nadeem ;

Domingo, Enric ;

Kanu, Nnennaya ;

Dewhurst, Sally M. ;

Gronroos, Eva ;

Chew, Su Kit ;

Rowan, Andrew J. ;

Schenk, Arne ;

Sheffer, Michal ;

Howell, Michael ;

Kschischo, Maik ;

Behrens, Axel ;

Helleday, Thomas ;

Bartek, Jiri ;

Tomlinson, Ian R. ;

Swanton, Charles .

NATURE, 2013, 494 (7438) :492-496

[8]

Targeting Chromosomal Instability and Tumour Heterogeneity in HER2-Positive Breast Cancer [J].

Burrell, Rebecca A. ;

Juul, Nicolai ;

Johnston, Stephen R. ;

Reis-Filho, Jorge S. ;

Szallasi, Zoltan ;

Swanton, Charles .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 111 (04) :782-790

[9]

The patterns and dynamics of genomic instability in metastatic pancreatic cancer [J].

Campbell, Peter J. ;

Yachida, Shinichi ;

Mudie, Laura J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

Stebbings, Lucy A. ;

Morsberger, Laura A. ;

Latimer, Calli ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena A. ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Griffin, Constance A. ;

Burton, John ;

Swerdlow, Harold ;

Quail, Michael A. ;

Stratton, Michael R. ;

Iacobuzio-Donahue, Christine ;

Futreal, P. Andrew .

NATURE, 2010, 467 (7319) :1109-1113

[10]

Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer [J].

Chen, Chun-Liang ;

Mahalingam, Devalingam ;

Osmulski, Pawel ;

Jadhav, Rohit R. ;

Wang, Chiou-Miin ;

Leach, Robin J. ;

Chang, Tien-Cheng ;

Weitman, Steven D. ;

Kumar, Addanki Pratap ;

Sun, LuZhe ;

Gaczynska, Maria E. ;

Thompson, Ian M. ;

Huang, Tim Hui-Ming .

PROSTATE, 2013, 73 (08) :813-826

← 1 2 3 4 5 6 7 8 9 →